BIP! Finder - 1‐Cinnamyl‐4‐(2‐methoxyphenyl)piperazines: Synthesis, Binding Properties, and Docking to Dopamine (D2) and Serotonin (5‐HT1A) Receptors

2007 • 1‐Cinnamyl‐4‐(2‐methoxyphenyl)piperazines: Synthesis, Binding Properties, and Docking to Dopamine (D2) and Serotonin (5‐HT1A) Receptors

Authors: Penjišević, Jelena, Šukalović, Vladimir, Andrić, Deana, Kostić Rajačić, Slađana, Šoškić, Vukić, Roglić, Goran

Venue: Archiv der Pharmazie

Type: Publication

Abstract: AbstractClinical properties of atypical antipsychotics are based on their interaction with D2 dopamine receptor and serotonin 5‐HT1A and 5‐HT2A receptors. As a part of our research program on new antipsychotics, we synthesized various derivatives of 1‐cinnamyl‐4‐(2‐methoxyphenyl)piperazines, and evaluated their affinities for D2, 5‐HT1A, 5‐HT2A, and adrenergic (α1) receptors using radioligand‐binding assays. In addition, we performed docking analysis using models for the D2 and 5‐HT1A receptors. All compounds exhibited low ... (read more)

Topics: Stereochemistry

DOI: 10.1002/ardp.200700062

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External links: Crossref OpenAIRE

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