BIP! Finder - Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields

2009 • Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields

Authors: Drakulić, Branko J., Stavri, Michael, Gibbons, Simon, Žižak, Željko S., Verbić, Tatjana, Jiranic, Ivan O., Zloh, Mire

Venue: ChemMedChem

Type: Publication

Abstract: Staphylococcus aureus is a major communityand hospitalacquired pathogen. Reports of resistance to antibiotics, including the fluoroquinolone class, have placed a greater emphasis on the development of new drugs for the treatment of both methicillin(MRSA) and multidrug-resistant (MDR) S. aureus strains. Recently, mixed quinolonediketo acid derivatives, which are based on the scaffold of fluoroquinolone antibiotics, were shown to exert significant anti-HIV-1 potency. The g-diketo moiety is also found in tetracycline, and is therefore potentially ... (read more)

Topics: Computational biology Stereochemistry Combinatorial chemistry

DOI: 10.1002/cmdc.200900273

BIP! social metrics: 0 2
External links: Crossref OpenAIRE

BibTex PDF

Topic-specific impact indicators

Popularity:
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence:
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count:
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse:
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.