BIP! Finder - Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl hydrazinoacetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes

2006 • Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl hydrazinoacetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes

Authors: Nevenka, Malesević, Tatjana, Srdić, Sinisa, Radulović, Dusan, Sladić, Vesna, Ilija, Brceski, Katarina, Andelković

Venue: Journal of Inorganic Biochemistry

Type: Publication

Abstract: A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the comple... (read more)

Topics: Medicinal chemistry Organic chemistry Stereochemistry

DOI: 10.1016/j.jinorgbio.2006.07.002

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