BIP! Finder - Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

2010 • Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

Authors: Alexandru, Maria-Gabriela, Ćirković-Veličković, Tanja, Jitaru, Ioana, Grgurić-Šipka, Sanja, Draghici, Constantin

Venue: Open Chemistry

Type: Publication

Abstract: Abstract This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear ... (read more)

Topics: Nuclear chemistry Medicinal chemistry

DOI: 10.2478/s11532-010-0022-2

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External links: Crossref OpenAIRE

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