BIP! Finder - Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models

2016 • Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models

Authors: Muller, Christian D., Elshaflu, Hana, Bjelogrlić, Snežana, Christian, Todorović, Tamara, Rodić, Marko, Marinković, Aleksandar, Filipović, Nenad

Venue: Journal of Coordination Chemistry

Type: Publication

Abstract: Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M con... (read more)

Topics: Medicinal chemistry

DOI: 10.1080/00958972.2016.1232404 (Found 3 versions)

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