BIP! Finder - Influence of N-1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor

2006 • Influence of N-1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor

Authors: V Mario Zlatovic, Vladimir Sukalovic, V Sladjana Kostic-Rajacic, B Deana Andric, M Goran Roglic

Venue: Journal of the Serbian Chemical Society

Type: Publication

Abstract: Scrotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology. Several structurally different classes of ligands are known to bind to the 5-HT1A receptor, but arylpiperazine derivatives are among the most important ligands. In the work, docking analyses were used to explain the binding affinities of a series of ligands with different N-1 substituent. All ligands had ill common the arylpiperazine structure, while the N-1 substituent was modi... (read more)

Topics: Stereochemistry

DOI: 10.2298/jsc0611125z

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External links: Crossref OpenAIRE

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