BIP! Finder - X-Ray Crystal Structure of 10β-Hydroxy-4β,5β-epoxyestr-1-en-3,17-dione and Antitumor Activity of its Congeners

1999 • X-Ray Crystal Structure of 10β-Hydroxy-4β,5β-epoxyestr-1-en-3,17-dione and Antitumor Activity of its Congeners

Authors: Milić, Dragana, Kapor, A, Markov, B, Ribar, Strumpel, M, Juranić, Z., Gasic, MJ, Šolaja, Bogdan A.

Venue: Molecules

Type: Publication

Abstract: Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in the asymmetric unit each consisting of four fused rings with the C(10) beta-oriented hydroxy group and beta-oriented O atom bridging C(4) and C(5). The conformation of A ring in both conformers A and B is boat (B-3,B-6), while rings B and C ... (read more)

Topics: Stereochemistry Crystallography

DOI: 10.3390/41200338

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External links: Crossref OpenAIRE

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